Accolate (Zafirlukast) was approved by the FDA in September of 1996 to treat chronic asthma. Accolate was prescribed to 250,000 patients in the U.S. after only 10 months on the market. Zeneca Pharmaceuticals, the manufacturer of Accolate, informed healthcare professionals that rare cases of eosinophilia, worsening pulmonary symptoms, vasculitic rash, cardiac complications, and neuropathy sometimes presented as Churg Strauss Syndrome were to be included on the Precautions and Adverse Reactions sections of the insert package for the drug on July 22, 1997.
Certain side effects including rare cases of life-threatening hepatic liver failure began to be reported in 2000. People taking Accolate that are experiencing symptoms such as right upper quadrant abdominal pain, nausea, fatigue, itchiness, yellowish staining of skin, abnormal drowsiness, flu-like symptoms, anorexia, and enlarged liver should stop taking the drug immediately and seek medical attention as these symptoms often indica
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